The answer is horribly complicated, with long discussions about laminar or non-laminar flow, reynold's numbers, etc etc. It also makes a BIG difference if the pipe is "plugged" or not, the shape of the "plug", etc etc.
There's definitely no single answer to this one.
Back to the original question - the difference in resistance would obviously be huge, but it wouldn't be directly proportional to the densities of the two fluids. And it doesn't simply scale up as the speed goes up. Also the force changes hugely on the shape of the object, and the acceleration until the force is no longer felt is hugely different. Hence physiologically these are going to be two very different experiences.
One example - imagine if you change the shape, e.g. by putting your hand out. In the water flow situation, no major difference - a definite tug would be experienced but you'll survive. In the airflow situation with an "equivalent" airflow, i.e. one that gives the same sense of pressure, when you put your hand out it'll probably get ripped out of its socket! The difference is that it'll be accelerated to a much higher velocity.
So - MY conclusion is that there's no definite or simple answer to this one. You'd have to give the exact body shape to an aerodynamicist and let them program for weeks to get an answer. And I stick with my preferred location - whether in an open passage OR as a plug!
More importantly - where is this "tube"? Sounds like laying a reel there could be... challenging! Edit - ah, Weeki Watchee. I get it now...
Another edit - does the effort required to move aginst this flow go up linearly or not? This is of course the more interesting question. The answer is, no, and here's a nice little discussion: http://en.wikipedia.org/wiki/Drag_%28physics%29


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